Chemical Base Information
Chemical name 6-chloro-1,1-dioxo-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide
Synonyms Dichlothiazide; Dihydrochlorothiazide; Esidrex; Esidrix; HCTZ; Hydrochlorothiazide; HydroDIURIL; Hypothiazide; Oretic; Sectrazide;
Molecular Formula C7H8ClN3O4S2
Molecular Weight 297.74g/mol
Melting Point 273–275 °C
InChI Key JZUFKLXOESDKRF-UHFFFAOYSA-N
Appearance White to off-white crystalline powder.
Half Life 6 to 15 hours
Solubility Soluble in DMSO, not in water
Storage Condition Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).
Application For the treatment of high blood pressure and management of edema.
Testing Document Available
03 Hydrochlorothiazide General Description
Hydrochlorothiazide is used alone or in combination with other medications to treat high blood pressure. Hydrochlorothiazide is used to treat edema (fluid retention; excess fluid held in body tissues) caused by various medical problems, including heart, kidney, and liver disease and to treat edema caused by using certain medications including estrogen and corticosteroids. Hydrochlorothiazide is in a class of medications called diuretics (‘water pills’).
04 Hydrochlorothiazide History
Hydrochlorothiazide is a thiazide-type diuretic which has been used clinically for more than half a century. The drug has been widely used to treat hypertension globally and is relatively very safe. Hydrochlorothiazide acts on the distal convoluted tubules and inhibits the sodium chloride co-transporter system. This action leads to a diuretic action and loss of potassium in the urine. The half-life of hydrochlorothiazide varies from 6 to 12 hours. Of the thiazide diuretics, hydrochlorothiazide is the most frequently used for the treatment of hypertension. Unfortunately, over the past decade, the use of hydrochlorothiazide has been declining, and it is being replaced by the angiotensin-converting enzyme inhibitors, which overall are far more effective and have fewer adverse effects.