Buy Pindolol powder (13523-86-9) hplc≥98% – β-Agonist Wisepowder
Chemical Base Information
Chemical name 1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol
Synonyms Indapamide, Noranat, Fludex, Natrilix, Tertensif
Molecular Formula C14H20N2O2
Molecular Weight 365.8345 g/mol
Melting Point 168 – 172°C
InChI Key JZQKKSLKJUAGIC-UHFFFAOYSA-N
Appearance White to Off-White Solid
Half Life 3-4houes
Solubility Soluble in DMSO, not in water
Storage Condition Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).
Application Mixed β-adrenergic blocker and serotonin 5HT1A-receptor antagonist. Antihypertensive; antianginal; antiarrhythmic; antiglaucoma.
Testing Document Available
03 Pindolol (13523-86-9) General Description
Pindolol is a moderately lipophilic beta blocker.of β1- and β2-adrenergic receptors (β1- and β2-ARs; Kis = 2.6 and 4.8 nM, respectively) and a partial agonist of the β3-AR, stimulating adenylyl cyclase in membranes of cells expressing the human receptor. Pindolol is a SR-1A/SR-1B antagonist with similar affinity for each subtype. Pindolol acts as a partial agonist at mouse and human β3-AR (β3-adrenoceptors). Pindolol is an inhibitor of β1-AR.Pindolol is an aryloxypropanolamine derivative with antihypertensive property. Pindolol competitively binds to beta-adrenergic receptors, resulting in a decrease in beta-adrenergic activities In addition, this agent blocks serotonin (5-HT) 1A receptors, thereby increasing the available serotonin in the brain. Increased serotonin levels augment the antidepressant action of selective serotonin reuptake inhibitors and monoamine oxidase inhibitors.
04 Pindolol (13523-86-9) History
Pindolol has been investigated as an add-on drug to antidepressant therapy with SSRIs like fluoxetine in the treatment of depression since 1994. The rationale behind this strategy has its basis in the fact that pindolol is an antagonist of the serotonin 5-HT1A receptor.Presynaptic and somatodendritic 5-HT1A receptors act as inhibitory autoreceptors, inhibit serotonin release, and are pro-depressive in their action.