Chemical Base Information
Name Esmolol powder
Chemical name Benzenepropanoic acid, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, methyl ester
Synonyms Esmolol; (+-)-Esmolol; ASL 8052-001
Molecular Formula C16H25NO4
Molecular Weight 295.379 g/moll
Melting Point 48-50°C
InChI Key AQNDDEOPVVGCPG-UHFFFAOYSA-N
Solubility Soluble in DMSO
Storage Condition Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).
Application Esmolol is a cardioselective beta1 receptor blocking agent.
Testing Document Available
03 Esmolol powder (81147-92-4) General Description
Esmolol powder is a cardioselective beta-blocker used in parenteral forms in the treatment of arrhythmias and severe hypertension.
04 Esmolol powder (81147-92-4) History
Esmolol (trade name Brevibloc) powder is a cardioselective beta1 receptor blocker with rapid onset, a very short duration of action, and no significant intrinsic sympathomimetic or membrane stabilising activity at therapeutic dosages.
It is a class II antiarrhythmic. Esmolol decreases the force and rate of heart contractions by blocking beta-adrenergic receptors of the sympathetic nervous system, which are found in the heart and other organs of the body. Esmolol prevents the action of two naturally occurring substances: epinephrine and norepinephrine.
It was patented in 1980 and approved for medical use in 1987.