Name Carvedilol powder
Chemical name carvedilol
Synonyms Carvedilol (200 mg);Cadilan;Carca;Cardivas;Carloc;Carvas;Korvasan;Talliton
Molecular Formula C24H26N2O4
Molecular Weight 406.47 g/mol
Melting Point 113-117°C
InChI Key OGHNVEJMJSYVRP-UHFFFAOYSA-N
Appearance White crystalline powder
Half Life 7-10 hours
Solubility Carvedilol is reported to be freely soluble in DMSO; sol in methylene chloride, methanol; sparingly soluble in ethanol, isopropanol; and slightly soluble in ethyl ether
Storage Condition Store at room temperature away from light and moisture.
Application It can treat high blood pressure and heart failure. It can also reduce the risk of death after a heart attack.
Testing Document Available
03 Carvedilol powder (72956-09-3) General Description
Carvedilol powder is a non-selective beta blocker indicated in the treatment of mild to moderate congestive heart failure (CHF). It blocks beta-1 and beta-2 adrenergic receptors as well as the alpha-1 adrenergic receptors. Carvedilol is used to treat high blood pressure and heart failure. It is also used after a heart attack to improve the chance of survival if your heart is not pumping well. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.
04 Carvedilol powder (72956-09-3) History
Carvedilol powder is a multiple action drug that blocks β1-, β2- and α1- adrenoceptors, and has potent antioxidant properties. Carvedilol is the first drug of its kind to be approved for the treatment of congestive heart failure, and is now the standard of care for this devastating disease. The discovery and development of carvedilol encountered an adverse regulatory climate, skepticism by the cardiology community and hesitance by the company, and in the early 1990s, the fate of the drug was uncertain. Nonetheless, in the largest heart failure study conducted up until that point, carvedilol produced marked reductions in morbidity and mortality, and has given new hope to patients afflicted with congestive heart failure. The story behind carvedilol powder contains important observations and lessons for scientists, regulators and physicians.